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  • 《柳叶刀》(the lancet)2018年7月6日选登

    作者:The Lancet    来源:The Lancet    浏览量:    上传时间:2018-07-09 17:12:54

     
    Causes and incidence of community-acquired serious infections among young children in south Asia (ANISA): an observational cohort study
    Prof Samir K Saha, PhD†,'Correspondence information about the author Prof Samir K SahaEmail the author Prof Samir K Saha, Stephanie J Schrag, DrPhil†, Shams El Arifeen, DrPh, Prof Luke C Mullany, PhD, Mohammad Shahidul Islam, MSPH, Nong Shang, PhD, Shamim A Qazi, PhD, Anita K M Zaidi, SM, Prof Zulfiqar A Bhutta, PhD, Prof Anuradha Bose, MD, Prof Pinaki Panigrahi, PhD, Prof Sajid B Soofi, FCPS, Nicholas E Connor, MSc, Dipak K Mitra, PhD, Prof Rita Isaac, MD, Jonas M Winchell, PhD, Melissa L Arvay, PhD, Maksuda Islam, BA, Yasir Shafiq, MSc,
     
    Summary
    Background
    More than 500 000 neonatal deaths per year result from possible serious bacterial infections (pSBIs), but the causes are largely unknown. We investigated the incidence of community-acquired infections caused by specific organisms among neonates in south Asia.
     
    Methods
    From 2011 to 2014, we identified babies through population-based pregnancy surveillance at five sites in Bangladesh, India, and Pakistan. Babies were visited at home by community health workers up to ten times from age 0 to 59 days. Illness meeting the WHO definition of pSBI and randomly selected healthy babies were referred to study physicians. The primary objective was to estimate proportions of specific infectious causes by blood culture and Custom TaqMan Array Cards molecular assay (Thermo Fisher, Bartlesville, OK, USA) of blood and respiratory samples.
     
    Findings
    6022 pSBI episodes were identified among 63 114 babies (95·4 per 1000 livebirths). Causes were attributed in 28% of episodes (16% bacterial and 12% viral). Mean incidence of bacterial infections was 13·2 (95% credible interval [CrI] 11·2–15·6) per 1000 livebirths and of viral infections was 10·1 (9·4–11·6) per 1000 livebirths. The leading pathogen was respiratory syncytial virus (5·4, 95% CrI 4·8–6·3 episodes per 1000 livebirths), followed by Ureaplasma spp (2·4, 1·6–3·2 episodes per 1000 livebirths). Among babies who died, causes were attributed to 46% of pSBI episodes, among which 92% were bacterial. 85 (83%) of 102 blood culture isolates were susceptible to penicillin, ampicillin, gentamicin, or a combination of these drugs.
     
    Interpretation
    Non-attribution of a cause in a high proportion of patients suggests that a substantial proportion of pSBI episodes might not have been due to infection. The predominance of bacterial causes among babies who died, however, indicates that appropriate prevention measures and management could substantially affect neonatal mortality. Susceptibility of bacterial isolates to first-line antibiotics emphasises the need for prudent and limited use of newer-generation antibiotics. Furthermore, the predominance of atypical bacteria we found and high incidence of respiratory syncytial virus indicated that changes in management strategies for treatment and prevention are needed. Given the burden of disease, prevention of respiratory syncytial virus would have a notable effect on the overall health system and achievement of Sustainable Development Goal.
     
    Funding
    Bill & Melinda Gates Foundation
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